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Alpha tocopherol, as well as gamma tocopherol, targeting the neutral and acid sphingomyelinases (SMase) activities and key enzyme givenchy shoes of sphingolipid synthesis de novo, serine palmitoyl transferase, normalized the content of pro apoptotic and pro inflammatory lipid ceramide in the aged isolated hepatocytes.
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Besides, alpha tocopherol or N acetylcysteine (NAC) administration to old rats prevented ceramide accumulation and increased SM levels in the hippocampus of 24 month old rats.
The oxidative stress induced ceramide accumulation in the keratinocytes, neurons, and astrocytes can be blocked by a pretreatment of cells with the vitamin E, too.
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